Philip Salvatore Portoghese (born June 4, 1931) is an American medicinal chemist who has made notable contributions to the design and synthesis of ligands targeting opioid receptors.
He is a Distinguished Professor of Medicinal Chemistry at the University of Minnesota, Twin Cities.
He also served as the Editor-in-chief of the Journal of Medicinal Chemistry from 1972 to 2012, when the job was taken on by his departmental colleague, Gunda I.
Georg, who shares the Editor-in-chief position with Shaomeng Wang at the University of Michigan.